Pathology Outlines

Stains
CCR9 (CD199)

Author: Nat Pernick, M.D.

Topic Completed: 1 July 2013

Minor changes: 18 September 2019

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: CCR9

Page views in 2019: 38

Page views in 2020 to date: 16

Table of Contents

Cite this page: Pernick N. CCR9. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsccr9.html. Accessed June 2nd, 2020.

Definition / general

Also known as CDw199, GPR28, CC chemokine receptor 9
Chemokine receptor; mediates chemotaxis in response to thymus-expressed chemokine (TECK) selectively expressed in thymus and small intestine

Clinical features

Abnormal regulation of chemokine TECK and its receptor CCR9 in endometriotic milieu is involved in pathogenesis of endometriosis (Cell Mol Immunol 2010;7:51)
Has role in inflammatory bowel disease (Expert Opin Ther Targets 2009;13:297)
CCR9 and its ligand CCL25 have important role in breast cancer cell survival and resistance to cisplatin (World J Surg Oncol 2011;9:46)
Plays pivotal role in drug resistance and invasion in T-ALL, ovarian cancer (World J Surg Oncol 2010;8:62, J Ovarian Res 2010;3:15)

Uses by pathologists

Microscopic (histologic) description

Images hosted on other servers:

Ovary: normal and carcinoma

Virtual slides

Images hosted on other servers:

Cerebellum

Tonsil

Lymph node

Pancreas

Cerebral cortex

Spleen

Ovarian stroma cells

Bone marrow

Parathyroid

Prostate

Pancreatic cancer

Positive staining - normal

Small subset of immune cells: immature thymocytes, small intestine trafficking T cells, IgA-producing plasma cells (Immunobiology 2012;217:402)
Macrophages / monocytes, increased in rheumatoid arthritis (Arthritis Res Ther 2010;12:R161)

Positive staining - disease