Table of Contents
Definition / general | Clinical features | Uses by pathologists | Microscopic (histologic) images | Virtual slides | Positive staining - normal | Positive staining - diseaseCite this page: Pernick N. CCR9. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsccr9.html. Accessed January 20th, 2021.
Definition / general
- Also known as CDw199, GPR28, CC chemokine receptor 9
- Chemokine receptor; mediates chemotaxis in response to thymus-expressed chemokine (TECK) selectively expressed in thymus and small intestine
Clinical features
- Abnormal regulation of chemokine TECK and its receptor CCR9 in endometriotic milieu is involved in pathogenesis of endometriosis (Cell Mol Immunol 2010;7:51)
- Has role in inflammatory bowel disease (Expert Opin Ther Targets 2009;13:297)
- CCR9 and its ligand CCL25 have important role in breast cancer cell survival and resistance to cisplatin (World J Surg Oncol 2011;9:46)
- Plays pivotal role in drug resistance and invasion in T-ALL, ovarian cancer (World J Surg Oncol 2010;8:62, J Ovarian Res 2010;3:15)
Uses by pathologists
- None at this time
Virtual slides
Positive staining - normal
- Small subset of immune cells: immature thymocytes, small intestine trafficking T cells, IgA-producing plasma cells (Immunobiology 2012;217:402)
- Macrophages / monocytes, increased in rheumatoid arthritis (Arthritis Res Ther 2010;12:R161)
Positive staining - disease
- Ovarian cancer (Int J Oncol 2011;39:373, World J Surg Oncol 2010;8:62)