Topic Completed: 1 October 2013

Minor changes: 4 March 2019

Copyright: 2003-2015,, Inc.

PubMed Search: chaperones[title]

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. Chaperones. website. Accessed June 7th, 2020.
Definition / general
  • Proteins which help other proteins fold correctly by transient binding to interactive surfaces (hydrophobic areas), which otherwise might aggregate
  • Name is accurate since it has no actual positive effect but prevents negative effects
  • Important after environmental stress which causes proteins to unfold
  • As a translated protein grows, it becomes increasingly available to chaperones; the protein is released into the intracellular space only when it is folded enough to prevent aggregation
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