Stains & molecular markers
Chloroacetate esterase


Topic Completed: 1 October 2013

Minor changes: 14 December 2020

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PubMed Search: Chloroacetate esterase[title]

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. Chloroacetate esterase. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainschloroacetate.html. Accessed April 16th, 2021.
Definition / general
  • Also called specific esterase, naphthol AS-D chloroacetate esterase
  • Useful for demonstrating myeloid differentiation, although negative in 25% of cases, particularly with immature granulocytic and monocytic neoplasms (Arch Pathol Lab Med 2005;129:32)
  • Enzyme cytochemistry-positive: AML-M1, M2, microgranular M3; granulocytic sarcomas, neutrophils
  • Enzyme cytochemistry-negative: ALL
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