Stains & CD markers
Cytokeratin 10 (CK10, K10)


Last author update: 1 October 2013
Last staff update: 25 June 2021

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PubMed Search: CK10

Nat Pernick, M.D.
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Cite this page: Pernick N. Cytokeratin 10 (CK10, K10). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsck10.html. Accessed August 11th, 2022.
Definition / general
  • Molecular weight of 56.5 kDa
  • Partner of CK1
  • CK1 and CK10 are present in suprabasal terminally differentiating cells
  • Mutations in CK10 or CK1 cause epidermolytic hyperkeratosis / bullous congenital ichthyosiform erythroderma of Brocq (Hum Mol Genet 2006;15:1133, Dermatol Online J 2006;12:6); defects of CK10-CK1 protein network cause structural instability and weakness of keratinocytes, causing blistering, hyperproliferation and hyperkeratosis
  • CK10 is putative autoantigen in chronic, antibiotic resistant Lyme arthritis (J Immunol 2006;177:2486)
Uses by pathologists
Positive staining - normal
  • Epidermal spinous and granular cell layers
Positive staining - disease
Additional references
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