Stains & CD markers
CK17
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: CK17[title]
CK17
Author: Nat Pernick, M.D.
Last author update: 1 October 2013
Last staff update: 25 June 2021
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: CK17[title]
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - malignant | Negative staining | Microscopic (histologic) images | Additional referencesCite this page: Pernick N. Cytokeratin 17 (CK17, K17) . PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsck17.html. Accessed June 10th, 2023.
Definition / general
- Molecular weight of 48 kDa
- Basal type cytokeratin (also 34betaE12, CK5/6, CK14) of complex epithelia but not in stratified or simple epithelia (Eur J Cell Biol 1992;59:127)
- Rapidly induced in wounded stratified epithelia (also CK 6, CK16); regulates cell growth through binding to the adaptor protein 14-3-3sigma (Nature 2006;441:362)
- Mutations cause pachyonychia congenita type 2 (J Dermatol 2006;33:161) or steatocystoma multiplex (Br J Dermatol 1998;139:475)
Uses by pathologists
- Distinguish pancreatobiliary adenocarcinoma (CK17+) from extra-pancreatobiliary nonmucinous adenocarcinoma (CK17-, Am J Surg Pathol 2005;29:359)
- Distinguish cholangiocarcinoma (60% are CK17+) from hepatocellular carcinoma (CK17-, J Gastrointestin Liver Dis 2006;15:9)
- Distinguish renal urothelial carcinoma (CK5/CK6+, CK17+, vimentin-) from collecting duct carcinoma (CK5/CK6-, CK17-, vimentin+, Am J Surg Pathol 2005;29:747)
- Considered a marker of or associated with the basal phenotype (also CK 5/6, CK 14) of invasive or in situ ductal carcinoma of breast (Mod Pathol 2006;19:1506)
- Sensitive marker of sentinel nodal metastases by RT-PCR in oral squamous cell carcinoma (Clin Cancer Res 2006;12:2498)
Positive staining - normal
- Basal cells of complex epithelia
- Breast myoepithelial cells (references above)
- Cervical reserve and immature metaplastic cells (Cancer 1999;87:87)
- Hair shaft epithelia (Am J Dermatopathol 1997;19:335)
- Nail beds (NCBI)
- Sebaceous glands (Oncol Rep 2006;16:295)
- Urothelial metaplasia (Int J Gynecol Pathol 1999;18:125)
Positive staining - malignant
- Basal cell of skin (J Dermatol Sci 1998;17:15)
- Breast (references above)
- Cervical (J Clin Pathol 1999;52:41)
- Cervical squamous intraepithelial lesions (Cancer 1999;87:87)
- Cholangiocarcinoma (intrahepatic, Pathologe 2006;27:244)
- Laryngeal premalignant changes or squamous cell carcinoma (Ann Otol Rhinol Laryngol 2004;113:821)
- Pancreatobiliary (Am J Clin Pathol 2001;115:695)
- Squamous cell of head and neck (Anticancer Res 2005;25:2675)
- Thyroid (Hum Pathol 1999;30:1166)
- Urothelial (references above)
Negative staining
- Gastric adenocarcinoma (Hum Pathol 2004;35:576)
Microscopic (histologic) images
Images hosted on other servers:
Breast myoepithelial hyperplasia (fig 1j)
Additional references
- Gastric adenocarcinoma (OMIM 148069)
