Stains
Cytokeratin 2 (CK2, K2)
Copyright: 2003-2015, PathologyOutlines.com, Inc.
PubMed Search: ck2[title]
Cytokeratin 2 (CK2, K2)
Author: Nat Pernick, M.D.
Topic Completed: 1 October 2013
Minor changes: 4 March 2019
Copyright: 2003-2015, PathologyOutlines.com, Inc.
PubMed Search: ck2[title]
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Additional referencesCite this page: Pernick N. Cytokeratin 2 (CK2, K2). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsck2.html. Accessed August 12th, 2020.
Definition / general
- Molecular weight (CK2e) is 65.5-65.8 kDa
- Associates with CK10
- Mutations cause ichthyosis bullosa of Siemens (Br J Dermatol 2005;152:1353)
- K2e (epidermis) and K2p (palate) are encoded by separate genes, with < 75% identity at primary structural level; thus, are not true isoforms, although they cannot be distinguished by conventional 2D electrophoresis
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Skin (upper spinous and granular cells, Br J Dermatol 1999;140:582)
Additional references
