Cytokeratin 34 beta E12

Topic Completed: 1 July 2013

Minor changes: 5 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: 34betaE12[title]

Nat Pernick, M.D.
Page views in 2019: 13,281
Page views in 2020 to date: 7,059
Cite this page: Hamilton K, Pernick N. Cytokeratin 34 beta E12. website. Accessed July 13th, 2020.
Definition / general
  • High molecular weight keratin relatively specific for prostate basal cells
  • Reacts to CK1, CK5, CK10 and CK14 and possibly other keratins
  • Also called CK903, high molecular weight keratin
Uses by pathologists
Microscopic (histologic) images

Images hosted on Pathout server:

Contributed by Dr. Stephen J. Schultenover, Vanderbilt University, Tennessee

Thyroid anaplastic carcinoma

Images hosted on other servers:

Prostate: normal

Prostate: basal cell hyperplasia

Prostate: postatrophic hyperplasia

Atypical adenomatous hyperplasia

Staining without and with antigen retrieval

High grade PIN: with adenocarcinoma

Prostatic adenocarcinoma is negative with occasional positive benign glands

Adenoid basal cell tumor

Low grade bladder neoplasms

Positive staining - normal
Positive staining - not malignant
Positive staining - malignant
Negative staining
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