Stains & molecular markers
Cytokeratin 4 (CK4, K4)
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: ck4[title]
Cytokeratin 4 (CK4, K4)
Author: Nat Pernick, M.D.
Topic Completed: 1 October 2013
Minor changes: 15 December 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: ck4[title]
Table of Contents
Definition / general | Uses by pathologists | Case reports | Positive staining - normal | Additional referencesCite this page: Pernick N. Cytokeratin 4 (CK4, K4). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsck4.html. Accessed January 17th, 2021.
Definition / general
- Molecular weight is 59 kDa
- Associates with CK13
- Downregulated in head and neck squamous cell carcinoma (Acta Otolaryngol 2006;126:967)
Uses by pathologists
- No significant clinical use by pathologists
Case reports
- Young man with novel mutation in the keratin 4 gene causing white sponge naevus (Br J Dermatol 2003;148:1125)
Positive staining - normal
- Suprabasal cells of nonkeratinized stratified squamous epithelium of esophagus and cornea; also anus, larynx, pharynx, tongue (J Biol Chem 1998;273:23912)
Additional references
