Stains & molecular markers

Topic Completed: 1 December 2011

Minor changes: 14 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: CLDN18

Nat Pernick, M.D.
Page views in 2020: 145
Page views in 2021 to date: 5
Cite this page: Pernick N. Claudin18. website. Accessed January 18th, 2021.
Definition / general
  • Claudins are large family of tight junction proteins with 4 transmembrane domains
  • Claudins function to produce a seal between cells, with critical role in maintaining cell polarity
  • Claudin18, first described in 2001 (Mol Cell Biol 2001;21:7380) is highly conserved member, specific for gastric and lung tissue (Gene 2011;481:83)
  • Also called CLDN18
Clinical features
  • Membranous staining
Microscopic (histologic) images

Images hosted on other servers:

Normal lung and stomach (Claudin18 splice variant 2)

Pancreas: PanIN (left), infiltrating ductal carcinoma (right)

Carcinomas of
stomach, esophagus,
ovary (Claudin18
splice variant 2)

Positive staining - disease
Negative staining
Back to top
Image 01 Image 02