Stains & molecular markers
Claudin7
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: claudin7
Claudin7
Author: Nat Pernick, M.D.
Topic Completed: 1 July 2013
Minor changes: 14 December 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: claudin7
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: Pernick N. Claudin7. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsclaudin7.html. Accessed January 19th, 2021.
Definition / general
- Has full length form (211 amino acids) and C-terminal truncated form (158 amino acids)
- Also known as CLDN7
- Important in aspirin-induced gastric barrier loss (Am J Physiol Cell Physiol 2008;295:C800)
- Interpretation: membranous expression
- References: NCBI Entrez Gene
Uses by pathologists
- High expression may be poor prognostic factor in nasopharyngeal carcinoma (Hum Pathol 2010;41:944), ovarian carcinoma (expression in serous effusions, Hum Pathol 2008;39:747)
- Membranous claudin7 and negative claudin8 may differentiate chromophobe renal cell carcinoma from onococytoma (Hum Pathol 2009;40:206)
Microscopic (histologic) images
Images hosted on other servers:
Synovial sarcoma
Positive staining - normal
- Kidney (distal nephron epithelium), lung and prostate (J Membr Biol 2003;194:187)
Positive staining - disease
- Ovarian adenocarcinoma (Am J Clin Pathol 2007;127:928, Int J Gynecol Cancer 2008;18:1262)
- Pancreatic solid papillary neoplasm (Am J Surg Pathol 2009;33:768)
- Renal cell carcinoma, chromophobe type (67%, Arch Pathol Lab Med 2007;131:1541)
- Synovial sarcoma, biphasic (J Biol Chem 2006;281:38941)
