Stains & molecular markers
Clusterin
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: Clusterin[title] stain
Clusterin
Author: Nat Pernick, M.D.
Topic Completed: 1 October 2013
Minor changes: 14 December 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: Clusterin[title] stain
Cite this page: Pernick N. Clusterin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsclusterin.html. Accessed January 15th, 2021.
Definition / general
- Glycoprotein implicated in apoptosis and other cellular functions
- Strongly expressed in follicular dendritic cell tumors, weak/no expression in other dendritic cell tumors
- Among spindle cell neoplasms, has high sensitivity and specificity for follicular dendritic cell tumors (Mod Pathol 2005;18:260)
Positive staining - disease
- Anaplastic large cell lymphoma (80-100% of systemic cases, 40-60% of primary cutaneous cases), diffuse large B cell lymphoma (12%), carcinomas of breast, colon, pancreas, prostate
