Pathology Outlines

Stains
Clusterin

Author: Nat Pernick, M.D.

Topic Completed: 1 October 2013

Revised: 4 March 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Clusterin[title] stain

Page views in 2018: 365

Page views in 2019 to date: 330

Table of Contents

Definition / general | Positive staining - disease

Cite this page: Pernick N. Clusterin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsclusterin.html. Accessed October 20th, 2019.

Definition / general

Glycoprotein implicated in apoptosis and other cellular functions
Strongly expressed in follicular dendritic cell tumors, weak/no expression in other dendritic cell tumors
Among spindle cell neoplasms, has high sensitivity and specificity for follicular dendritic cell tumors (Mod Pathol 2005;18:260)

Positive staining - disease

Anaplastic large cell lymphoma (80-100% of systemic cases, 40-60% of primary cutaneous cases), diffuse large B cell lymphoma (12%), carcinomas of breast, colon, pancreas, prostate