Topic Completed: 1 October 2013

Minor changes: 27 August 2020

Copyright: 2003-2020,, Inc.

PubMed Search: c-MET[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. c-MET. website. Accessed September 20th, 2020.
Definition / general
  • Gene at 7q31-34; receptor for hepatocyte growth factor receptor
  • A tyrosine kinase that mediates cell motility, proliferation, invasiveness, angiogenesis and morphogenetic differentiation
  • Activating mutations are present in papillary renal cell carcinoma; missense mutation in 6% of thyroid carcinoma (papillary, follicular and medullary, Am J Surg Pathol 2005;29:544); high levels of MET mRNA and protein expressed in papillary thyroid carcinoma
Positive staining - disease
  • Melanoma, melanocytic lesions
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