Stains & molecular markers
c-MET


Topic Completed: 1 October 2013

Minor changes: 11 December 2020

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: c-MET[title]

Nat Pernick, M.D.
Page views in 2020: 298
Page views in 2021 to date: 18
Cite this page: Pernick N. c-MET. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscmet.html. Accessed January 20th, 2021.
Definition / general
  • Gene at 7q31-34; receptor for hepatocyte growth factor receptor
  • A tyrosine kinase that mediates cell motility, proliferation, invasiveness, angiogenesis and morphogenetic differentiation
  • Activating mutations are present in papillary renal cell carcinoma; missense mutation in 6% of thyroid carcinoma (papillary, follicular and medullary, Am J Surg Pathol 2005;29:544); high levels of MET mRNA and protein expressed in papillary thyroid carcinoma
Positive staining - disease
  • Melanoma, melanocytic lesions
Back to top
Image 01 Image 02