Stains & molecular markers
Collagen
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: collagen[title]
Collagen
Author: Nat Pernick, M.D.
Topic Completed: 1 October 2013
Minor changes: 11 December 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: collagen[title]
Cite this page: Pernick N. Collagen. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscollagen.html. Accessed January 19th, 2021.
Definition / general
- Type I collagen: dermis, tendons and bone
- Type II collagen: cartilage
- Type III collagen: fetal skin, scars, arterial walls
- Type IV collagen: normal constituent of basement membrane surrounding noninvasive glandular epithelium; discontinuous or complete absence of basement membrane staining surrounding colonic adenocarcinoma (Am J Surg Pathol 2002;26:206)
Uses by pathologists
- Double immunostaining of type IV collagen with cytokeratin is useful to detect microinvasion in VIN or CIN (Arch Pathol Lab Med 2005;129:747)
