Pathology Outlines

Stains
Collagen

Author: Nat Pernick, M.D.

Topic Completed: 1 October 2013

Revised: 4 March 2019

Copyright: 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: collagen[title]

Page views in 2018: 941

Page views in 2019 to date: 553

Table of Contents

Definition / general | Uses by pathologists | Microscopic (histologic) images

Cite this page: Pernick N. Collagen. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscollagen.html. Accessed July 21st, 2019.

Definition / general

Type I collagen: dermis, tendons and bone
Type II collagen: cartilage
Type III collagen: fetal skin, scars, arterial walls
Type IV collagen: normal constituent of basement membrane surrounding noninvasive glandular epithelium; discontinuous or complete absence of basement membrane staining surrounding colonic adenocarcinoma (Am J Surg Pathol 2002;26:206)

Uses by pathologists

Double immunostaining of type IV collagen with cytokeratin is useful to detect microinvasion in VIN or CIN (Arch Pathol Lab Med 2005;129:747)

Microscopic (histologic) images

Images hosted on other servers:

CIN/VIN: double immunostaining with cytokeratin