Stains & molecular markers
CXCR2
Copyright: 2003-2020, PathologyOutlines.com, Inc.
PubMed Search: Cxcr2 stain
CXCR2
Author: Nat Pernick, M.D.
Topic Completed: 1 January 2012
Minor changes: 3 September 2020
Copyright: 2003-2020, PathologyOutlines.com, Inc.
PubMed Search: Cxcr2 stain
Table of Contents
Definition / general | Terminology | Diagrams / tables | Interpretation | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CXCR2. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscxcr2.html. Accessed September 21st, 2020.
Definition / general
- Interleukin 8 receptor beta subunit (IL8RB); binds multiple CXC chemokines including IL-8 (CXCL8)
- Chemokine receptor, powerful neutrophil chemotactic factor, particularly to sites of inflammation
Terminology
- Also called CD182; formerly called CD128b
Diagrams / tables
Images hosted on other servers:
Inflammatory infiltration
Interpretation
- Cytoplasmic staining
Uses by pathologists
- No significant uses by pathologists
Microscopic (histologic) images
Images hosted on other servers:
Ovarian carcinoma
Positive staining - normal
- Mature granulocytes, keratinocytes, neuroendocrine cells, projection neurons (Arch Pathol Lab Med 2000;124:520)
Positive staining - disease
- Carcinoid tumor (classic, atypical, metastatic), pituitary adenoma, pheochromocytoma, medullary carcinoma
Negative staining
- Parathyroid cells
- Small cell carcinoma of lung/cervix, large cell lung neuroendocrine carcinoma, Merkel cell carcinoma, neuroblastoma, melanoma
