Cite this page: Pernick N. CXCR3. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscxcr3.html. Accessed January 20th, 2021.
Definition / general
- Also called CD183
- Receptor for some chemokines; binding of chemokines to CD183 induces integrin activation, cytoskeletal changes and chemotactic migration in inflammation-associated effector T cells
- CD183+ T cells detected in inflamed tissues of patients with juvenile rheumatoid arthritis, multiple sclerosis, sarcoidosis, hepatitis C
Positive staining - normal
- T cells in inflamed tissue, eosinophils, plasmacytoid dendritic cells, hematopoietic progenitors
- Naïve T cells in peripheral blood