Pathology Outlines

Stains
CXCR5

Author: Nat Pernick, M.D.

Topic Completed: 1 December 2011

Minor changes: 31 August 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: cxcr5

Page views in 2019: 127

Page views in 2020 to date: 90

Table of Contents

Cite this page: Pernick N. CXCR5. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscxcr5.html. Accessed September 20th, 2020.

Definition / general

Multi-pass membrane protein of CXC chemokine receptor family

Terminology

Also called CD185, BLR1 (Burkitt lymphoma receptor 1)

Pathophysiology

Binds to B Lymphocyte Chemoattractant (BLC / CXCL13, J Exp Med 1998;187:655); involved in B cell migration into B cell follicles of spleen and Peyer patches (J Immunol 2009;182:2610)
Critical for function of follicular helper T (TFH) cells
May have role in survival and maintainance of cardiac structure upon pressure overload by regulating proteoglycans essential for correct collagen assembly (PLoS One 2011;6:e18668)
May be important for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori induced inflammation (J Mol Med (Berl) 2010;88:1169)
During HIV1 infection, altered expression of CXCR5/CXCL13 may cause B cell dysfunction (Blood 2008;112:4401)
Upregulated in rheumatoid arthritis synovial tissue and expressed in various cell types (Arthritis Res Ther 2005;7:R217)