Stains
CXCR5
Revised: 18 December 2018, last major update December 2011
Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.
PubMed Search: cxcr5
CXCR5
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2011
Revised: 18 December 2018, last major update December 2011
Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.
PubMed Search: cxcr5
Table of Contents
Definition / general | Terminology | Pathophysiology | Interpretation | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: Pernick N. CXCR5. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscxcr5.html. Accessed June 7th, 2020.
Definition / general
- Multi-pass membrane protein of CXC chemokine receptor family
Terminology
- Also called CD185, BLR1 (Burkitt lymphoma receptor 1)
Pathophysiology
- Binds to B Lymphocyte Chemoattractant (BLC / CXCL13, J Exp Med 1998;187:655); involved in B cell migration into B cell follicles of spleen and Peyer patches (J Immunol 2009;182:2610)
- Critical for function of follicular helper T (TFH) cells
- May have role in survival and maintainance of cardiac structure upon pressure overload by regulating proteoglycans essential for correct collagen assembly (PLoS One 2011;6:e18668)
- May be important for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori induced inflammation (J Mol Med (Berl) 2010;88:1169)
- During HIV1 infection, altered expression of CXCR5/CXCL13 may cause B cell dysfunction (Blood 2008;112:4401)
- Upregulated in rheumatoid arthritis synovial tissue and expressed in various cell types (Arthritis Res Ther 2005;7:R217)
Interpretation
- Cytoplasmic staining
Uses by pathologists
- No significant uses by pathologists
Microscopic (histologic) images
Left: chronic H. pylori gastris (fig F); right: MALT lymphoma (fig E)
AIDS related non-Hodgkin lymphoma is CXCR5+
Synovium of non-rheumatoid arthritis (left) and rheumatoid arthritis (right)
Positive staining - normal
- Mature B cells
Positive staining - disease
- Burkitt's lymphoma, mantle cell lymphoma (Blood 2009;113:4604); AIDS-related non-Hodgkin lymphoma (AIDS Res Treat 2010;2010:164586)
