Stains & CD markers
deltaNp63 (p40)


Topic Completed: 1 January 2012

Minor changes: 18 June 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: deltaNp63 [title]

Nat Pernick, M.D.
Page views in 2020: 15,150
Page views in 2021 to date: 8,854
Cite this page: Pernick N. deltaNp63. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsdeltaNp63.html. Accessed August 2nd, 2021.
Definition / general
  • One of 10 p63 isoforms (J Virol 2007;81:11569), important to classify non small cell lung cancer into adenocarcinoma (p40-) versus squamous cell carcinoma (p40+), which determines chemotherapy regimen
  • Truncated, nontransactivating isoform highly specific for squamous / basal cells
Terminology
Clinical features
  • Mutations cause ectrodactyly-ectodermal dysplasia-cleft syndrome, ankyloblepharon-ectodermal dysplasia-clefting syndrome, nonsyndromic split-hand/split-foot malformation (J Cell Sci 2011;124:2200)
Uses by pathologists
Microscopic (histologic) images

Contributed by Andrey Bychkov, M.D., Ph.D.

Lung SCC



Images hosted on other servers:
Missing Image

Hidradeno-carcinoma, metastatic to lymph node

Missing Image

Lung, various tumors

Missing Image

Oral preneoplastic lesions (OPL)

Positive staining - normal
Positive staining - disease
Negative staining
Back to top
Image 01 Image 02