Stains & CD markers

Last author update: 1 July 2016
Last staff update: 25 June 2021

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PubMed Search: Dicer [title]

Rebecca Obeng, M.D.
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Cite this page: Obeng R. Dicer. website. Accessed April 14th, 2024.
Definition / general
  • Protein encoded by DICER1 gene on chromosome 14
  • A ribonuclease that produces 21 - 23 nucleotide short interfering RNAs (siRNAs) and microRNAs (miRNAs) by cleaving long double stranded RNAs (dsRNAs) and pre-miRNAs
Essential features
  • Dicer 1, ribonuclease III, Dcr-1 homolog, helicase MOI, HERNA, helicase with RNA motif, Double stranded RNA specific endoribonuclease
  • The prevalence and penetrance of the mutations are not known
  • Dicer syndrome is a rare disorder
  • Ubiquitously expressed
  • Unknown
Clinical features
  • Depends on the neoplastic process
  • The levels of dicer may be useful in the diagnosis of cancer
  • Decreased expression identified in patients with tumors (Cancer Res 2010;70:2571)
Radiology description
  • Radiologic features depends on the presenting disease
Prognostic factors
Case reports
  • Depends on the present disease
  • Surgical resection with or without chemotherapy
  • Patients with pleuropulmonary blastoma may also undergo radiation therapy
Microscopic (histologic) description
  • Cytoplasmic staining
Microscopic (histologic) images

Images hosted on other servers:

Dicer expression in benign prostatic epithelium

Expression in urinary bladder

Expression of
dicer in neoplastic
prostate tissue

Positive stains
Negative stains
Molecular / cytogenetics description
  • Deletions, insertions, missense mutations, nonsense mutations, splice variants
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