Stains & CD markers
DOG1

Editorial Board Member: Christian M. Schürch, M.D., Ph.D.
Deputy Editor-in-Chief: Catherine E. Hagen, M.D.
Nick Baniak, M.D.

Topic Completed: 2 September 2021

Minor changes: 2 September 2021

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PubMed Search: DOG1[title] "last 5 years"[DP]

Nick Baniak, M.D.
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Cite this page: Baniak N. DOG1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsdog1.html. Accessed October 21st, 2021.
Definition / general
  • Discovered on GIST 1
  • Primarily used in the diagnosis of gastrointestinal stromal tumor (GIST)
Essential features
  • Monoclonal (SP31, K9, DOG1.1) and polyclonal antibodies (Cancer Control 2015;22:498)
  • Most sensitive and specific marker for GIST
Pathophysiology
Interpretation
  • Membranous and cytoplasmic
Uses by pathologists
Microscopic (histologic) images

Contributed by Nick Baniak, M.D.
H&E resection

Resection

H&E biopsy

Biopsy

Diffuse staining Diffuse staining

Diffuse staining

Diffuse staining Diffuse staining

Diffuse staining

Positive staining - normal
Positive staining - disease
Negative staining
Sample pathology report
  • Stomach, biopsy:
    • Gastrointestinal stromal tumor (see comment)
    • Comment: Immunohistochemistry performed at X institution reveals the following immunoprofile (controls stained appropriately): positive - DOG1.
Board review style question #1

DOG1 may be a particularly important biomarker for GISTs with which mutation, due to the more frequent finding of CD117 and CD34 negativity?

  1. KIT
  2. NF
  3. PDGFRα
  4. SDH
Board review style answer #1
C. PDGFRα

Comment Here

Reference: DOG1
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