Stains
Dynactin1
Copyright: 2002-2015, PathologyOutlines.com, Inc.
PubMed Search: Dynactin1
Dynactin1
Author: Nat Pernick, M.D.
Topic Completed: 1 November 2012
Minor changes: 5 March 2019
Copyright: 2002-2015, PathologyOutlines.com, Inc.
PubMed Search: Dynactin1
Table of Contents
Definition / general | Case reports | Uses by pathologists | Diagrams / tables | Microscopic (histologic) images | Positive staining - normalCite this page: Pernick N. Dynactin1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsdynactin1.html. Accessed June 2nd, 2020.
Definition / general
- Also called DCTN1
- Dynactin is largest of 10 subunits that make up a complex involved in:
- ER-Golgi transport
- Centripetal movement of lysosomes and endosomes
- Spindle formation
- Chromosome movement
- Nuclear positioning
- Axonogenesis
- retrograde axonal transport (Neuropathology 2012;32:458)
- Complex binds to Dynein intermediate chain (Cell Migration Consortium)
- Mutations cause Perry syndrome (Parkinsonism Relat Disord 2010;16:612, Nat Genet 2009;41:163, Gene Reviews - Perry Syndrome)
- Mutations are only occasionally associated with ALS (Neurology 2009;72:2024, J Neuropathol Exp Neurol 2007;66:617), frontal temporal dementia and motor neuron disease (J Neurosci 2010;30:13729)
Case reports
- 7 year old girl with fusion of dynactin 1 to anaplastic lymphoma kinase in inflammatory myofibroblastic tumor (Hum Pathol 2012;43:2047)
Uses by pathologists
- No specific uses at this time
Diagrams / tables
Dynactin protein complex
Microscopic (histologic) images
Perry syndrome
Positive staining - normal
- Dynactin subunits p50 and p62 are useful for immunohistochemistry; Dynactin p150 is not
