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Stains & molecular markers
EBER1, EBER2 and LMP

Nat Pernick, M.D.

Topic Completed: 1 June 2005

Minor changes: 31 March 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: EBER1 [title] EBER2

Nat Pernick, M.D.
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Table of Contents
Epstein Barr Virus | EBER1 & EBER2 | LMP | Microscopic (histologic) images
Cite this page: Pernick N. EBER1 and EBER2. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainseber1.html. Accessed April 18th, 2021.
Epstein Barr Virus
  • Strongly associated with sinonasal (NK) lymphomas
  • Associated with monoclonal B cell lymphoproliferative disorder (high grade) and immunosuppression (methotrexate) for autoimmune disease
  • Expresses LMP1, which prevents apoptosis via bcl2 interaction
  • Expresses EBER1, which transactivates host genes
EBER1 & EBER2
  • EBV encoded RNA
    • Nuclear RNA portions of EBER 1 and 2 genes
  • Interpretation: nuclear stain
LMP
  • Latent Membrane Protein of EBV
  • Interpretation: cytoplasmic or membranous staining
Microscopic (histologic) images

Contributed by Andrey Bychkov, M.D., Ph.D.
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EBER ISH, high power

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LMP in EBV+ nasopharyngeal carcinoma

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