Stains & molecular markers
EBER1, EBER2 and LMP
Topic Completed: 1 June 2005
Minor changes: 31 March 2021
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: EBER1 [title] EBER2
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Cite this page: Pernick N. EBER1 and EBER2. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainseber1.html. Accessed April 18th, 2021.
Epstein Barr Virus
- Strongly associated with sinonasal (NK) lymphomas
- Associated with monoclonal B cell lymphoproliferative disorder (high grade) and immunosuppression (methotrexate) for autoimmune disease
- Expresses LMP1, which prevents apoptosis via bcl2 interaction
- Expresses EBER1, which transactivates host genes
EBER1 & EBER2
- EBV encoded RNA
- Nuclear RNA portions of EBER 1 and 2 genes
- Interpretation: nuclear stain
LMP
- Latent Membrane Protein of EBV
- Interpretation: cytoplasmic or membranous staining
Microscopic (histologic) images
Contributed by Andrey Bychkov, M.D., Ph.D.
LMP in EBV+ nasopharyngeal carcinoma
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