Stains & molecular markers
Factor XIIIa
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: Factor XIIIa
Factor XIIIa
Author: Nat Pernick, M.D.
Topic Completed: 1 August 2012
Minor changes: 9 November 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: Factor XIIIa
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. Factor XIIIa. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsfactorxiiia.html. Accessed April 19th, 2021.
Definition / general
- Fibrohistiocytic marker; note that peritumoral cells may also exhibit Factor XIIIa staining
- Also active form of factor XIII, an enzyme of coagulation system that crosslinks fibrin (Wikipedia: Factor XIII [Accessed 2 August 2018])
Uses by pathologists
- Marker of fibrohistiocytic proliferations
- Marker of dermal dencrocytes
- Differentiate dermatofibrosarcoma protuberans (CD34+, D2-40-, Factor XIIIa-) from dermatofibroma (CD34-, Factor XIIIa+, D2-40+)
Microscopic (histologic) images
Case #116
Epithelioid fibrous histiocytoma
Images hosted on other servers:
Atypical fibroxanthoma
Positive staining - normal
- Dermal dendrocytes
Positive staining - disease
- Soft tissue: benign fibrous histiocytoma and variants, malignant fibrous histiocytoma
- Also calcifying fibrous tumor (Mod Pathol 2001;14:784), verruciform xanthoma
- Also atypical fibroxanthoma (focal), hemangiopericytoma (scattered), myofibroblastoma in lymph nodes (variable), pleomorphic hyalinizing angiectatic tumor (focal), storiform collagenoma (scattered)
- Cervix: aggressive angiomyxoma
- CNS: Erdheim-Chester disease
Negative staining
- Dermatofibrosarcoma protuberans (usually), Langerhans cell histiocytosis
- Solitary fibrous tumor (Int J Gynecol Pathol 2010;29:189)
