Factor XIIIa

Topic Completed: 1 August 2012

Minor changes: 5 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: Factor XIIIa

Nat Pernick, M.D.
Page views in 2019: 5,571
Page views in 2020 to date: 3,553
Cite this page: Pernick N. Factor XIIIa. website. Accessed August 14th, 2020.
Definition / general
Uses by pathologists
  • Marker of fibrohistiocytic proliferations
  • Marker of dermal dencrocytes
  • Differentiate dermatofibrosarcoma protuberans (CD34+, D2-40-, Factor XIIIa-) from dermatofibroma (CD34-, Factor XIIIa+, D2-40+)
Microscopic (histologic) images

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Epithelioid fibrous histiocytoma

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Atypical fibroxanthoma

Positive staining - normal
  • Dermal dendrocytes
Positive staining - disease
  • Soft tissue: benign fibrous histiocytoma and variants, malignant fibrous histiocytoma
  • Also calcifying fibrous tumor (Mod Pathol 2001;14:784), verruciform xanthoma
  • Also atypical fibroxanthoma (focal), hemangiopericytoma (scattered), myofibroblastoma in lymph nodes (variable), pleomorphic hyalinizing angiectatic tumor (focal), storiform collagenoma (scattered)
  • Cervix: aggressive angiomyxoma
  • CNS: Erdheim-Chester disease
Negative staining
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