Stains & molecular markers
HLA-G
Copyright: 2003-2020, PathologyOutlines.com, Inc.
PubMed Search: HLA-G[title]
HLA-G
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2005
Minor changes: 1 September 2020
Copyright: 2003-2020, PathologyOutlines.com, Inc.
PubMed Search: HLA-G[title]
Cite this page: Pernick N. HLA-G. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainshlag.html. Accessed September 20th, 2020.
Definition / general
- Non-classical MHC class I antigen that interacts with NK cells, can present nonamer peptides and binds CD8 analogous to classic HLA class 1 proteins
- May play a role in maternal tolerance toward fetal tissue
- Sensitive and specific for intermediate trophoblast in all types of gestational trophoblastic tissue (including tumors) in initial study (Am J Surg Pathol 2002;26:914)
- Focal staining in melanoma, renal cell carcinoma, large cell carcinoma of the lung
Negative staining
- Cytotrophoblast, syncytiotrophoblast
