Stains & CD markers
IDH1 (R132H)

Topic Completed: 1 November 2013

Minor changes: 22 July 2021

Copyright: 2015-2021,, Inc.

PubMed Search: IDH1 stain

Nat Pernick, M.D.
Page views in 2020: 6,161
Page views in 2021 to date: 6,314
Cite this page: Pernick N. IDH1 (R132H). website. Accessed October 28th, 2021.
Definition / general
Diagrams / tables

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Role in TCA cycle

Catalyzation of wild-type and mutant IDH1 and IDH2 reactions

Uses by pathologists
  • Bone: IDH1/2 mutation may differentiate chondrosarcoma (mutation present) from chondroblastic osteosarcoma (mutation not present, Am J Surg Pathol 2013;37:787); presence of IDH1/2 mutations may confirm diagnosis of dedifferentiated chondrosarcoma if osteosarcomatous differentiation present
  • CNS - glioma and glioblastoma:
Microscopic (histologic) images

Contributed by GenomeMe

Astrocytoma, IDH1-R132H, clone IHC132

Glioma. IDH1-R132H, clone IHC132

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Kidney: normal

Oligoastrocytoma, anaplastic


Positive staining - disease
Negative staining
  • Primary glioblastoma (includes small cell, granular cell, giant cell variants)
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