Stains & molecular markers

Topic Completed: 1 November 2013

Minor changes: 8 September 2020

Copyright: 2015-2020,, Inc.

PubMed Search: IDH1 stain

Nat Pernick, M.D.
Page views in 2019: 5,382
Page views in 2020 to date: 4,437
Cite this page: Pernick N. IDH1. website. Accessed September 21st, 2020.
Definition / general
Diagrams / tables

Images hosted on other servers:

Role in TCA cycle

Catalyzation of wild-type and mutant IDH1 and IDH2 reactions

Uses by pathologists
  • Bone: IDH1/2 mutation may differentiate chondrosarcoma (mutation present) from chondroblastic osteosarcoma (mutation not present, Am J Surg Pathol 2013;37:787); presence of IDH1/2 mutations may confirm diagnosis of dedifferentiated chondrosarcoma if osteosarcomatous differentiation present
  • CNS - glioma and glioblastoma:
Microscopic (histologic) images

Contributed by GenomeMe

Astrocytoma, IDH1-R132H, clone IHC132

Glioma. IDH1-R132H, clone IHC132

Images hosted on other servers:

Kidney: normal

Oligoastrocytoma, anaplastic


Positive staining - disease
Negative staining
  • Primary glioblastoma (includes small cell, granular cell, giant cell variants)
Back to top
Image 01 Image 02