Cite this page: Pernick N. Iron. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsiron.html. Accessed August 8th, 2020.
Definition / general
- Also called hemosiderin (storage iron granules)
- See also Hales colloidal iron
- Perls method (Prussian blue stain): hydrochloric acid releases the protein bound to ferric iron, then potassium ferrocyanide binds with ferric iron to form ferric ferrocyanide, an insoluble blue compound (Wikipedia)
- Hemosiderin may be present in areas of old hemorrhage or be deposited in tissues with iron overload
- Hemosiderosis: stored iron does not interfere with organ function vs. hemochromatosis: iron overload associated with organ failure