Topic Completed: 1 June 2005

Minor changes: 6 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: Iron[title]

Nat Pernick, M.D.
Page views in 2019: 3,166
Page views in 2020 to date: 2,167
Cite this page: Pernick N. Iron. website. Accessed August 8th, 2020.
Definition / general
  • Also called hemosiderin (storage iron granules)
  • See also Hales colloidal iron
  • Perls method (Prussian blue stain): hydrochloric acid releases the protein bound to ferric iron, then potassium ferrocyanide binds with ferric iron to form ferric ferrocyanide, an insoluble blue compound (Wikipedia)
  • Hemosiderin may be present in areas of old hemorrhage or be deposited in tissues with iron overload
  • Hemosiderosis: stored iron does not interfere with organ function vs. hemochromatosis: iron overload associated with organ failure
Microscopic (histologic) images

Hemosiderin, liver, iron stain


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