Topic Completed: 1 June 2005

Minor changes: 6 March 2019

Copyright: 2003-2015,, Inc.

PubMed Search: Lambda[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Lambda. website. Accessed August 11th, 2020.
Definition / general
  • Type of immunoglobulin light chain
  • Kappa/lambda ratio is usually 2:1
  • Restricted expression of either kappa or lambda suggests monoclonality and a neoplastic process
Microscopic (histologic) images

Images hosted on Pathout server:

Hodgkin lymphoma: neoplastic cells have
variable cytoplasmic lambda staining, plasma
cells have intense staining and histiocytes
have weak staining

Contributed by Leica Microsystems, Biosytems division:
Myeloma of bone marrow with ISH staining for
kappa (left) and lambda (right) light chains using
Kappa Probe (PB0645), Lambda Probe (PB0669)
and Bond Polymer Refine Detection

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