Stains & molecular markers

Topic Completed: 1 December 2011

Minor changes: 3 September 2020

Copyright: 2002-2020,, Inc.

Nat Pernick, M.D.
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Cite this page: Pernick N. LIN28. website. Accessed September 20th, 2020.
Definition / general
  • First characterized in 2003 (Dev Biol 2003;258:432)
  • RNA-binding protein that maintains pluripotency of embryonic stem cells
Clinical features
  • Cytoplasmic staining
Uses by pathologists
Microscopic (histologic) images

Contributed by Epitomics


Positive staining - disease
  • Germ cell tumors: intratubular germ cell neoplasia, embryonal carcinoma, seminoma, dysgeminoma, yolk sac tumor, gonadoblastoma
  • Variable staining in teratoma, choriocarcinoma, spermatocytic seminoma
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