Stains & molecular markers
LIN28
Copyright: 2002-2020, PathologyOutlines.com, Inc.
LIN28
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2011
Minor changes: 3 September 2020
Copyright: 2002-2020, PathologyOutlines.com, Inc.
Table of Contents
Definition / general | Clinical features | Interpretation | Uses by pathologists | Microscopic (histologic) images | Positive staining - diseaseCite this page: Pernick N. LIN28. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainslin28.html. Accessed September 20th, 2020.
Definition / general
- First characterized in 2003 (Dev Biol 2003;258:432)
- RNA-binding protein that maintains pluripotency of embryonic stem cells
Clinical features
- May regulate glucose metabolism (Cell 2011;147:81)
Interpretation
- Cytoplasmic staining
Uses by pathologists
- Diagnostic marker comparable to SALL4 for germ cell tumors (testicular, ovarian and extragonadal): intratubular germ cell neoplasia, seminoma, dysgerminoma, embryonal carcinoma, yolk sac tumor (Hum Pathol 2011;42:710, Histopathology 2011;59:452, Mod Pathol 2011;24:288)
Microscopic (histologic) images
Contributed by Epitomics
Seminoma
Positive staining - disease
- Germ cell tumors: intratubular germ cell neoplasia, embryonal carcinoma, seminoma, dysgeminoma, yolk sac tumor, gonadoblastoma
- Variable staining in teratoma, choriocarcinoma, spermatocytic seminoma
