Stains & molecular markers
Mammaglobin


Topic Completed: 1 December 2015

Minor changes: 25 September 2020

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PubMed Search: Mammaglobin [title]

Meenakshi Vij Gupta, M.D.
Page views in 2020: 5,358
Page views in 2021 to date: 269
Cite this page: Gupta MV. Mammaglobin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsmammaglobin.html. Accessed January 19th, 2021.
Definition / general
  • Belongs to the family of small epithelial secretory proteins (secretoglobins) of the uteroglobin / Clara cell protein family
Uses by pathologists
Clinical features
  • While some expression is seen in normal breast, its expression is markedly increased in breast carcinoma (positive expression has been reported in 48 - 72.1% of mammary adenocarcinomas) and is directly correlated with a higher grade
  • Also, mammaglobin expression is said to be higher in lobular carcinomas than ductal carcinomas and in ER positive tumors
Case reports
Microscopic (histologic) images

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Infiltrating ductal carcinoma

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Infiltrating mammary carcinoma


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Normal breast glands

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Various breast cancers

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Endometrial carcinoma

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