Stains & molecular markers

Topic Completed: 1 June 2005

Minor changes: 4 November 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Melanin [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Melanin. website. Accessed January 20th, 2021.
Definition / general
  • Pigment normally found in skin, eye, substantia nigra, melanomas
  • Melanin stains are Fontana-Masson (stains melanin black) and Schmorl method (stains melanin blue-green)
  • Bleaching with potassium permanganate or hydrogen peroxide is used to remove melanin to examine cellular morphology
  • Note: pseudomelanin of melanosis coli, usually found in macrophages, is PAS positive; true melanin is not
Microscopic (histologic) images

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Melanoma, Fontana-Masson stain

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