Cite this page: Pernick N. Melanin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsmelanin.html. Accessed January 20th, 2021.
Definition / general
- Pigment normally found in skin, eye, substantia nigra, melanomas
- Melanin stains are Fontana-Masson (stains melanin black) and Schmorl method (stains melanin blue-green)
- Bleaching with potassium permanganate or hydrogen peroxide is used to remove melanin to examine cellular morphology
- Note: pseudomelanin of melanosis coli, usually found in macrophages, is PAS positive; true melanin is not