Mesothelin

Stains
Mesothelin

Author: Nat Pernick, M.D.

Topic Completed: 1 June 2005

Revised: 7 March 2019

Copyright: 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: Mesothelin [title]

Page views in 2018: 461

Page views in 2019 to date: 546

Table of Contents

Definition / general | Positive staining - normal | Positive staining - disease | Negative staining

Cite this page: Pernick N. Mesothelin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsmesothelin.html. Accessed November 12th, 2019.

Definition / general

40 kDa differentiation antigen; precursor protein’s amino portion is megakaryocytic potentiating factor
Cytoplasmic membrane glycoprotein found on surface of mesothelial cells, mesothelioma, ovarian carcinoma, pancreatic adenocarcinoma
May place a role in cellular adhesion

Positive staining - normal

Mesothelial cells

Positive staining - disease

Mesothelioma, ovarian surface carcinoma

Negative staining

Benign bile duct lesions