Stains & molecular markers
Mesothelin
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: Mesothelin [title]
Mesothelin
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2005
Minor changes: 23 December 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: Mesothelin [title]
Table of Contents
Definition / general | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. Mesothelin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsmesothelin.html. Accessed January 22nd, 2021.
Definition / general
- 40 kDa differentiation antigen; precursor protein’s amino portion is megakaryocytic potentiating factor
- Cytoplasmic membrane glycoprotein found on surface of mesothelial cells, mesothelioma, ovarian carcinoma, pancreatic adenocarcinoma
- May place a role in cellular adhesion
Positive staining - normal
- Mesothelial cells
Positive staining - disease
- Mesothelioma, ovarian surface carcinoma
Negative staining
- Benign bile duct lesions
