Stains & CD markers
MSH1
Copyright: 2016-2023, PathologyOutlines.com, Inc.
PubMed Search: MSH1 [title]
MSH1
Author: Sheren Younes, M.D., Ph.D.
Last author update: 1 August 2016
Last staff update: 18 June 2021
Copyright: 2016-2023, PathologyOutlines.com, Inc.
PubMed Search: MSH1 [title]
Table of Contents
Definition / generalCite this page: Younes S. MSH1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsmsh1.html. Accessed June 10th, 2023.
Definition / general
- The four key human mismatch repair genes identified to date are MutL Homologue 1 (MLH1), MutS Homologue 2 (MSH2), MutS Homologue 6 (MSH6), and PostMeiotic Segregation increased 2 (PMS2), homologous to the E. coli MMR genes
- MSH1 gene is not found in humans
- MSH1 encodes a protein homologous to the Escherichia coli Mut S and Streptococcus pneumonia Hex A protein
- It is important for mitochondrial DNA repair and stability
- It binds to base-base and small insertion-deletion mismatches in mRNA
- In plants, its suppression leads to emergence of abnormal plant phenotypes (Nat Commun 2015;6:6386)
- In yeast, its loss of function causes a petite phenotype (Genetics 1992;132:975)
