Topic Completed: 1 May 2012

Minor changes: 28 August 2020

Copyright: 2002-2020,, Inc.

PubMed Search: mTOR [title]

Nat Pernick, M.D.
Page views in 2019: 88
Page views in 2020 to date: 74
Cite this page: Pernick N. mTOR. website. Accessed September 20th, 2020.
Definition / general
  • Mammalian Target Of Rapamycin
  • Also known as mechanistic target of rapamycin, FK506 binding protein 12 rapamycin associated protein 1 / FRAP1 (Wikipedia)
  • Member of PI3 kinase related family
  • Protein encoded by FRAP1 gene
  • Serine / threonine protein kinase that regulates cell growth, proliferation, motility and survival
  • Also protein synthesis and transcription
Clinical features
Uses by pathologists
  • None at this time
Microscopic (histologic) images

Images hosted on other servers:
Missing Image


Positive staining - disease
  • Thyroid: papillary carcinoma (cytoplasmic and variable nuclear staining, Mod Pathol 2011;24:1553)
  • RICTOR, a major component of the mTOR complex 2, is significantly overexpressed in well differentiated leiomyosarcoma (Mod Pathol 2012;25:197)
Back to top
Image 01 Image 02