Stains & molecular markers

Topic Completed: 1 June 2005

Minor changes: 23 December 2020

Copyright: 2002-2021,, Inc.

PubMed Search: MUC5AC [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. MUC5AC. website. Accessed January 22nd, 2021.
Definition / general
  • Also known as MUC5 (GeneCards)
  • Protects epithelium
Positive staining - normal
  • Stomach (foveolar epithelium of body and antrum), tracheobronchial mucosa, endometrium (mucinous metaplasia, eosinophilic change / metaplasia (Mod Pathol 2005;18:1243), surface syncytial change, ciliated change in 52%)
Positive staining - disease
  • Extramammary Paget disease but not mammary Paget disease or normal breast tissue (Am J Surg Pathol 2001;25:1469)
  • Mucinous carcinoma of ovary, diffuse type gastric carcinoma (83%)
Negative staining
  • Normal breast tissue
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