Molecular markers
MyoD1
Author: Nat Pernick, M.D.
Last author update: 1 June 2005
Last staff update: 8 August 2022
Copyright: 2002-2022, PathologyOutlines.com, Inc.
PubMed Search: MyoD1 [title]
Table of Contents
Definition / general | Interpretation | Positive staining - normal | Negative stainingCite this page: Pernick N. MyoD1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsmyod1.html. Accessed August 10th, 2022.
Definition / general
- Myogenic transcriptional regulatory protein expressed early in skeletal muscle differentiation
- Sensitive but not specific for rhabdomyosarcoma due to cytoplasmic and non-specific background staining (Am J Surg Pathol 2001;25:1150)
- Stronger staining in alveolar vs. embryonal rhabdomyosarcomasar germ cell tumors (also other cells as indicated below)
Interpretation
- Nuclear immunostaining
Positive staining - normal
- Normal fetal muscle
Negative staining
- Normal adult muscle
