Stains & molecular markers
MyoD1
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: MyoD1 [title]
MyoD1
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2005
Minor changes: 23 December 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: MyoD1 [title]
Table of Contents
Definition / general | Interpretation | Positive staining - normal | Negative stainingCite this page: Pernick N. MyoD1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsmyod1.html. Accessed April 19th, 2021.
Definition / general
- Myogenic transcriptional regulatory protein expressed early in skeletal muscle differentiation
- Sensitive but not specific for rhabdomyosarcoma due to cytoplasmic and non-specific background staining (Am J Surg Pathol 2001;25:1150)
- Stronger staining in alveolar vs. embryonal rhabdomyosarcomasar germ cell tumors (also other cells as indicated below)
Interpretation
- Nuclear immunostaining
Positive staining - normal
- Normal fetal muscle
Negative staining
- Normal adult muscle
