Molecular markers

MyoD1



Last author update: 1 June 2005
Last staff update: 8 August 2022

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PubMed Search: MyoD1 [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. MyoD1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsmyod1.html. Accessed August 10th, 2022.
Definition / general
  • Myogenic transcriptional regulatory protein expressed early in skeletal muscle differentiation
  • Sensitive but not specific for rhabdomyosarcoma due to cytoplasmic and non-specific background staining (Am J Surg Pathol 2001;25:1150)
  • Stronger staining in alveolar vs. embryonal rhabdomyosarcomasar germ cell tumors (also other cells as indicated below)
Interpretation
  • Nuclear immunostaining
Positive staining - normal
  • Normal fetal muscle
Negative staining
  • Normal adult muscle
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