Stains & CD markers
NFP / neurofilament

Last author update: 1 June 2005
Last staff update: 22 July 2021

Copyright: 2002-2024,, Inc.

PubMed Search: Neurofilament [title]

Nat Pernick, M.D.
Page views in 2024 to date: 1,083
Cite this page: Pernick N. NFP / neurofilament. website. Accessed April 14th, 2024.
Definition / general
  • Major cytoskeletal element in nerve axons and dendrites
  • Consist of three distinct polypeptides, the neurofilament triplet
  • Metabolism appears to be disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, and by severe reduction of gene expression for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients
Positive staining - normal
  • Neuronal cells
Positive staining - disease
  • Central neurocytoma
  • Neuroblastoma
  • Medulloblastoma
  • Retinoblastoma
  • Merkel cell tumor of skin
  • Pancreatic endocrine neoplasms
  • Carcinoid tumors
  • Parathyroid tumors
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