Table of Contents
Definition / generalCite this page: Pernick N. NF 2. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsnf2.html. Accessed January 20th, 2021.
Definition / general
- Tumor suppressor protein at 22q11-13.1
- Produces protein called merlin or schannomin
- Deleted in soft tissue perineurioma
- Both copies inactivated in up to 60% of sporadic meningiomas
- Often no protein expression in schwannoma
- May be involved in tumorigenesis of schwannoma and some meningiomas