Stains & molecular markers
NF2
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: NF2 [title]
NF2
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2005
Minor changes: 23 December 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: NF2 [title]
Table of Contents
Definition / generalCite this page: Pernick N. NF 2. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsnf2.html. Accessed January 20th, 2021.
Definition / general
- Tumor suppressor protein at 22q11-13.1
- Produces protein called merlin or schannomin
- Deleted in soft tissue perineurioma
- Both copies inactivated in up to 60% of sporadic meningiomas
- Often no protein expression in schwannoma
- May be involved in tumorigenesis of schwannoma and some meningiomas
