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Stains
NF2

Nat Pernick, M.D.

Topic Completed: 1 June 2005

Minor changes: 7 March 2019

Copyright: 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: NF2 [title]


Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. NF 2. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsnf2.html. Accessed June 7th, 2020.
Definition / general
  • Tumor suppressor protein at 22q11-13.1
  • Produces protein called merlin or schannomin
  • Deleted in soft tissue perineurioma
  • Both copies inactivated in up to 60% of sporadic meningiomas
  • Often no protein expression in schwannoma
  • May be involved in tumorigenesis of schwannoma and some meningiomas
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