Stains & molecular markers
NPM-ALK fusion protein

Topic Completed: 1 June 2005

Minor changes: 30 September 2020

Copyright: 2002-2021,, Inc.

PubMed Search: NPM-ALK fusion protein [title]

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. NPM-ALK fusion protein. website. Accessed January 16th, 2021.
Definition / general
  • Formed by consistent breakpoints in t(2;5)(p23;q35)
  • Has truncated NPM and ALK proteins
  • Contains only constitutively active catalytic domain of ALK
  • Fusion protein found in anaplastic large cell lymphoma (13 - 50%)
    • When present, can be used to differentiate from Hodgkin lymphoma
  • Patients with fusion protein appear to have better prognosis
  • Appears to phosphorylate / activate members of multiple signaling pathways influencing cell proliferation and apoptosis, including ras, Grb2, Shc, IRS-1, JAK / STAT, PI3-kinase / AKT and FOX03a
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