Stains & CD markers
NPM1
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: NPM1 [title]
NPM1
Author: Nat Pernick, M.D.
Last author update: 1 June 2005
Last staff update: 20 August 2021
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: NPM1 [title]
Table of Contents
Definition / generalCite this page: Pernick N. NPM1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsnpmalk.html. Accessed March 28th, 2023.
Definition / general
- Formed by consistent breakpoints in t(2;5)(p23;q35)
- Has truncated NPM and ALK proteins
- Contains only constitutively active catalytic domain of ALK
- Fusion protein found in anaplastic large cell lymphoma (13 - 50%)
- When present, can be used to differentiate from Hodgkin lymphoma
- Patients with fusion protein appear to have better prognosis
- Appears to phosphorylate / activate members of multiple signaling pathways influencing cell proliferation and apoptosis, including ras, Grb2, Shc, IRS-1, JAK / STAT, PI3-kinase / AKT and FOX03a
