Stains & CD markers

Last author update: 1 June 2005
Last staff update: 20 August 2021

Copyright: 2002-2023,, Inc.

PubMed Search: NPM1 [title]

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. NPM1. website. Accessed March 28th, 2023.
Definition / general
  • Formed by consistent breakpoints in t(2;5)(p23;q35)
  • Has truncated NPM and ALK proteins
  • Contains only constitutively active catalytic domain of ALK
  • Fusion protein found in anaplastic large cell lymphoma (13 - 50%)
    • When present, can be used to differentiate from Hodgkin lymphoma
  • Patients with fusion protein appear to have better prognosis
  • Appears to phosphorylate / activate members of multiple signaling pathways influencing cell proliferation and apoptosis, including ras, Grb2, Shc, IRS-1, JAK / STAT, PI3-kinase / AKT and FOX03a
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