Stains & CD markers
Pancreatic polypeptide (PP)

Topic Completed: 1 February 2016

Minor changes: 23 July 2021

Copyright: 2016-2022,, Inc.

PubMed Search: Pancreatic polypeptide [title]

Meenakshi Vij Gupta, M.D.
Page views in 2021: 209
Page views in 2022 to date: 5
Cite this page: Gupta M. Pancreatic polypeptide. website. Accessed January 19th, 2022.
Definition / general
  • PP is synthesized as the amino portion of a larger 95 amino acid precursor
  • The biological activity is located in the carboxyl hexapeptide and requires the C terminal amide
  • PP belongs to a family of homologous peptides that also includes Peptide YY (PPY) and Neuropeptide Y (NPY)
  • Its secretion usually involves vagal-cholinergic stimulation, resulting in effects on GI motility, exocrine pancreas secretion, gallbladder contraction, hepatic glucose secretion and food intake (Pancreapedia - Pancreatic Polypeptide)
  • The PP cells are primarily located peripherally in the Islets of Langerhans but can also be scattered throughout the exocrine pancreas and in the pancreatic duct epithelium
  • PP located outside of the islets is infrequent in humans (Makhlouf: Handbook of Physiology: The Gastrointestinal System, Volume II, 1989)
  • Pancreatic polypeptide receptor 1, also known as Neuropeptide Y receptor type 4, is a protein that in humans is encoded by the PPYR1 gene (Genomics 1997;46:287)
Uses by pathologists
  • PP cells can be identified in pancreatic polypeptide cell hyperplasia (PPCH), PPomas (tumors composed exclusively or mostly of pancreatic polypeptide cells) and mixed pancreatic neuroendocrine tumor
Case reports
Microscopic (histologic) images

Images hosted on other servers:
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Endocrine cell cluster

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Endocrine cell population expresses PP

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Various images

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Islet of Langerhans

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