Topic Completed: 1 June 2005

Minor changes: 7 March 2019

Copyright: 2002-2015,, Inc.

PubMed Search: PCNA [title]

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. PCNA. website. Accessed August 3rd, 2020.
Definition / general
  • Proliferating Cell Nuclear Antigen
  • Also called cyclin
  • Nonhistone 36 kDa nuclear protein with a role in DNA synthesis, DNA repair, and cell cycle progression
  • Coordinates synthesis of both leading and lagging strands at the replication fork during DNA replication
  • Expression correlates with proliferation activity
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