Stains & molecular markers
PHF1
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: PHF1 [title]
PHF1
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2014
Minor changes: 8 September 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: PHF1 [title]
Cite this page: Pernick N. PHF1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsphf1.html. Accessed January 17th, 2021.
Definition / general
- Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis (J Biol Chem 2013;288:529)
- PHF1 gene rearrangement present in 80% of ossifying fibromyxoid tumors (benign, atypical and malignant lesions, Am J Pathol 2012;181:1069, Am J Surg Pathol 2013;37:1751), with fusion to EP400 in 44% of cases (Genes Chromosomes Cancer 2014;53:183)
- Endometrial stromal sarcoma with sex cord differentiation is associated with PHF1 rearrangement (Am J Surg Pathol 2013;37:514)
- Unusual ossifying sarcoma of the heart demonstrated JAZF1 / PHF1 fusion (Am J Surg Pathol 2013;37:938)
Uses by pathologists
- No uses at this time
