Stains & molecular markers

Topic Completed: 1 January 2013

Minor changes: 21 September 2020

Copyright: 2002-2021,, Inc.

PubMed Search: PPAR gamma [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. PPARγ. website. Accessed January 17th, 2021.
Definition / general
  • Peroxisome Proliferator Activated Receptor γ
  • PAX8 / PPARγ fusion protein is produced by t(2;3)(q13;p25), occurs frequently in follicular thyroid carcinoma; diffuse strong nuclear staining correlates with PAX8-PPARγ detected by RT-PCR in follicular carcinoma or adenoma (Am J Surg Pathol 2002;26:1016)
  • PPARγ agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function, and may protect against neurodegenerative changes associated with neuroinflammation (J Neuroinflammation 2012;9:63, Mol Neurobiol 2012;46:114)
  • Decreases inflammatory response of many cardiovascular cells, particularly endothelial cells
  • Controls adipocyte differentiation and regulates many genes associated with energy homeostasis
    • Its gene polymorphisms influence obesity and obesity phenotype in a complex manner, probably involving insulin resistance in north Indian population (Am J Hum Biol 2012;24:454)
Uses by pathologists
  • No significant uses at this time
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive staining - normal
  • High expression in fat, low expression in liver, very low expression in muscle
Molecular / cytogenetics images

Contributed by LeicaBiosystems Amsterdam

PPARG (3p25)

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