Stains
PPAR γ
Copyright: 2002-2017, PathologyOutlines.com, Inc.
PubMed Search: PPAR gamma [title]
PPAR γ
Author: Nat Pernick, M.D.
Topic Completed: 1 January 2013
Minor changes: 8 March 2019
Copyright: 2002-2017, PathologyOutlines.com, Inc.
PubMed Search: PPAR gamma [title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Molecular / cytogenetics imagesCite this page: Pernick N. PPARγ. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsppargamma.html. Accessed June 2nd, 2020.
Definition / general
- Peroxisome Proliferator Activated Receptor γ
- PAX8 / PPARγ fusion protein is produced by t(2;3)(q13;p25), occurs frequently in follicular thyroid carcinoma; diffuse strong nuclear staining correlates with PAX8-PPARγ detected by RT-PCR in follicular carcinoma or adenoma (Am J Surg Pathol 2002;26:1016)
- PPARγ agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function, and may protect against neurodegenerative changes associated with neuroinflammation (J Neuroinflammation 2012;9:63, Mol Neurobiol 2012;46:114)
- Decreases inflammatory response of many cardiovascular cells, particularly endothelial cells
- Also blocks fibrogenic TGF-beta responses in vitro and in vivo (Arthritis Res Ther 2012;14:R102)
- Controls adipocyte differentiation and regulates many genes associated with energy homeostasis
- Its gene polymorphisms influence obesity and obesity phenotype in a complex manner, probably involving insulin resistance in north Indian population (Am J Hum Biol 2012;24:454)
Uses by pathologists
- No significant uses at this time
Microscopic (histologic) images
Various images
Positive staining - normal
- High expression in fat, low expression in liver, very low expression in muscle
Molecular / cytogenetics images
Images hosted on PathOut server:
Images kindly provided by LeicaBiosystems Amsterdam:
PPARG (3p25)
