Prostate specific membrane antigen (PSMA)

Topic Completed: 1 August 2016

Minor changes: 2 June 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Prostate specific membrane antigen [title]

Sheren Younes, M.D.
Page views in 2019: 1,253
Page views in 2020 to date: 494
Cite this page: Younes S. Prostate specific membrane antigen (PSMA). website. Accessed June 2nd, 2020.
Definition / general
  • 750 Amino acid, 100 KDa, type II membrane glycoprotein with both folate hydrolase and N-acetylated-alpha-linked-acidic peptidase (NAALAD) activity
  • Assists with folate uptake and modulates excitatory neurotransmissions in brain
  • In contrast to PSA, upregulated with androgen deprivation (Rev Urol 2004;6:S13)
Diagrams / tables

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Uses by pathologists
  • Cytoplasmic or membranous staining
Positive staining - normal
  • Prostate epithelial cells; also adrenal gland, bladder, breast, esophagus, fallopian tube, kidney, large intestine, liver, ovary, small intestine, spinal cord, stomach, testis
Negative staining - normal
  • Prostate basal and stromal cells
Positive staining - tumors
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