Stains & CD markers
PU.1
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: PU.1 [title]
PU.1
Author: Nat Pernick, M.D.
Last author update: 1 June 2012
Last staff update: 23 July 2021
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: PU.1 [title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - disease | Negative stainingCite this page: Pernick N. PU.1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainspu1.html. Accessed June 7th, 2023.
Definition / general
- Ets family transcription factor, also known as Spleen focus forming virus Proviral Integration site-1 (Spi1)
- Transcription factor that plays an essential role in development of lymphoid and myeloid cells by regulating IL7 receptor or macrophage-colony stimulating factor
- Low PU.1 levels upregulate IL7 receptor expression on common lymphoid progenitor cells, while high levels of PU.1 prevent IL7 receptor expression
- PU.1 expression is dynamically controlled throughout haematopoiesis to direct appropriate lineage specification (Int J Cell Biol 2011;2011:808524)
- Nuclear staining
Uses by pathologists
- Differentiate classic Hodgkin lymphoma (PU.1 negative) from nodular lymphocyte predominant Hodgkin lymphoma (PU.1+, Mod Pathol 2006;19:1010)
Microscopic (histologic) images
Images hosted on other servers:
Histiocytic sarcoma
B ALL and T ALL
Positive staining - disease
- Nodular lymphocyte predominant Hodgkin lymphoma (100%)
- Follicular lymphoma, mantle cell lymphoma, marginal zone B cell lymphoma, small lymphocytic lymphoma (100%)
- Histiocytic / dendritic cell sarcoma (100%, Mod Pathol 2011;24:1421)
- 50% of diffuse large B cell lymphoma
Negative staining
- Classical Hodgkin lymphoma (Reed-Sternberg and Hodgkin cells)
- Downregulated in CML (Int J Hematol 2012;96:65)
