Topic Completed: 1 June 2005

Minor changes: 7 March 2019

Copyright: 2003-2019,, Inc.

PubMed Search: RCC[title]

Nat Pernick, M.D.
Page views in 2019: 4,482
Page views in 2020 to date: 2,909
Cite this page: Pernick N. RCC. website. Accessed August 3rd, 2020.
Definition / general
  • Also called RCC Ma (Renal Cell Carcinoma Marker)
  • Mouse monoclonal antibody generated against crude microsomal fraction of proximal tubules from normal human kidney
  • Specific for glycoprotein in renal proximal tubular brush border
  • Sensitive and specific for primary renal cell carcinoma (Am J Surg Pathol 2001;25:1485)
  • Positive in 93% of primary and 67%-84% of metastatic renal cell carcinomas
  • Most clear cell (84%) or papillary RCCs were positive, compared to 0% to 56% of chromophobe carcinomas, 0% sarcomatoid carcinomas, 0% collecting duct carcinomas, 0% oncocytomas
Microscopic (histologic) images

Images hosted on other servers:

Pulmonary adenocarcinoma metastasis (left) to renal cell carcinoma (right):
CK7 (2A); TTF1 (2B); RCC (2C)

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