Stains & molecular markers
RCC
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: RCC[title]
RCC
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2005
Minor changes: 9 December 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: RCC[title]
Table of Contents
Definition / generalCite this page: Pernick N. RCC. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsrcc.html. Accessed April 15th, 2021.
Definition / general
- Also called RCC Ma (Renal Cell Carcinoma Marker)
- Mouse monoclonal antibody generated against crude microsomal fraction of proximal tubules from normal human kidney
- Specific for glycoprotein in renal proximal tubular brush border
- Sensitive and specific for primary renal cell carcinoma (Am J Surg Pathol 2001;25:1485)
- Positive in 93% of primary and 67%-84% of metastatic renal cell carcinomas
- Most clear cell (84%) or papillary RCCs were positive, compared to 0% to 56% of chromophobe carcinomas, 0% sarcomatoid carcinomas, 0% collecting duct carcinomas, 0% oncocytomas
