Stains & CD markers
S100P
Copyright: 2002-2024, PathologyOutlines.com, Inc.
S100P
Author: Nat Pernick, M.D.
Last author update: 1 December 2011
Last staff update: 12 August 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
Table of Contents
Definition / general | Pathophysiology | Interpretation | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. S100P. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainss100p.html. Accessed April 18th, 2024.
Definition / general
- 95 amino acid calcium-binding protein first purified from placenta in 1992 (Eur J Biochem 1992;207:541); 95 amino acid calcium-binding protein; may initiate carcinogenesis in some epithelial tumors
- Caution: S100 (the neural / melanocytic marker) is also described as S100p or S100P in the literature
Pathophysiology
- Intracellular S100P interacts with ezrin, and extracellular S100P activates the receptor for advanced glycation endproducts
- Associated with aggressive disease in peripheral intrahepatic cholangiocarcinoma (Am J Surg Pathol 2011;35:590)
Interpretation
- Nuclear and cytoplasmic staining
Uses by pathologists
- Diagnose pancreatic adenocarcinoma in FNA specimens (Am J Clin Pathol 2008;129:81, Diagn Cytopathol 2011 Apr 28 [Epub ahead of print])
- Differentiate bile duct adenocarcinoma from reactive lesions at biopsy, as part of a immunohistochemical panel with pVHL and IMP3 (Hum Pathol 2010;41:1210)
- Differentiate urothelial carcinoma (S100P+ in 78-86%) from prostatic adenocarcinoma (S100P-)
- Possible biological indicator (due to downregulation) of cadmium toxicity in placentas (Sci Total Environ 2011;410:53)
Microscopic (histologic) images
Images hosted on other servers:
Various normal tissues
Left: colon dysplasia and carcinoma; right - various carcinomas
Pancreas: normal, PanIN, adenocarcinoma
Positive staining - normal
- mRNA - high levels: esophagus and placenta; mRNA - moderate levels: colon, duodenum, prostate, stomach, white blood cells (BMC Clin Pathol 2008 Feb 18;8:2)
- Protein - high levels: placenta and stomach
Positive staining - disease
- GI, liver, lung carcinomas
- Ovarian carcinoma and ovarian Brenner tumors (Am J Surg Pathol 2009;33:347)
- Pancreatic ductal adenocarcinoma (56%), PanIN (90%, Am J Surg Pathol 2008;32:78), IPMN (Hum Pathol 2010;41:824)
- Salivary glands-carcinoma ex pleomorphic adenoma (Am J Surg Pathol 2011;35:346)
- Urothelial carcinoma (78-86%, Am J Surg Pathol 2007;31:673)
Negative staining
- Pancreas (normal), prostatic adenocarcinoma, renal cell carcinoma
