Stains & CD markers

Last author update: 1 December 2011
Last staff update: 12 August 2021

Copyright: 2002-2024,, Inc.

Nat Pernick, M.D.
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Cite this page: Pernick N. S100P. website. Accessed May 19th, 2024.
Definition / general
  • 95 amino acid calcium-binding protein first purified from placenta in 1992 (Eur J Biochem 1992;207:541); 95 amino acid calcium-binding protein; may initiate carcinogenesis in some epithelial tumors
  • Caution: S100 (the neural / melanocytic marker) is also described as S100p or S100P in the literature
  • Intracellular S100P interacts with ezrin, and extracellular S100P activates the receptor for advanced glycation endproducts
  • Associated with aggressive disease in peripheral intrahepatic cholangiocarcinoma (Am J Surg Pathol 2011;35:590)
  • Nuclear and cytoplasmic staining
Uses by pathologists
Microscopic (histologic) images

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Various normal tissues

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Left: colon dysplasia and carcinoma; right - various carcinomas

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Pancreas: normal, PanIN, adenocarcinoma

Positive staining - normal
  • mRNA - high levels: esophagus and placenta; mRNA - moderate levels: colon, duodenum, prostate, stomach, white blood cells (BMC Clin Pathol 2008 Feb 18;8:2)
  • Protein - high levels: placenta and stomach
Positive staining - disease
Negative staining
  • Pancreas (normal), prostatic adenocarcinoma, renal cell carcinoma
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