Stains & molecular markers
Special AT-rich sequence-binding protein 2 (SATB2)

Topic Completed: 1 February 2017

Minor changes: 25 February 2021

Copyright: 2017-2021,, Inc.

PubMed Search: Special AT-rich sequence-binding protein 2 OR SATB2

Angela M.Y. Chan, M.Sc.
Page views in 2020: 14,032
Page views in 2021 to date: 4,711
Cite this page: Chan A. Special AT-rich sequence-binding protein 2 (SATB2). website. Accessed April 15th, 2021.
Definition / general
  • Regulates transcription and chromatin remodeling
  • Binds to matrix attachment regions (MAR) of DNA and induces a local chromatin loop remodeling
  • Contains 2 consensus SUMO acceptor sites
  • Can be sumoylated by SUMO E3 Ligase PIAS1
  • Defects in sumoylation sites is associated with gene activation and SATB2 is targeted to nuclear periphery upon sumoylation (Genes Dev 2003;17:3048)
  • Mutant SATB2 has a dominant-negative effect on wild type protein (Hum Genet 2013;132:1383)
  • Involved in vertebrate skeletogenesis via repression of HOXA2 gene (inhibitor of bone formation and regulator of branchial arch patterning) (Cell 2006;125:971)
  • SATB2 knockout mice show defects in osteoblast differentiation via interaction to RUNX2 and ATF4 (transcription factors that regulate osteoblast differentiation) (Cell 2006;125:971, Stem Cells Dev 2013;22:2278)
Diagrams / tables

Images hosted on other servers:

Comparison of clinical features of patients

SATB2 and Cancer

Clinical features
Uses by pathologists
Prognostic factors
Case reports
Clinical images

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3 year old patient with SATB2 R239X mutation

10 year old patient showing mild dysmorphic features

Microscopic (histologic) images

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images of SATB2
staining in CRC

Virtual slides

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Various images

Positive stains
  • Brain
  • Branchial arch
  • Sites of bone formation
  • Kidney
  • Gut
  • Colon
  • Lymphoid cells
Negative stains
  • Liver
  • Lung
  • Pancreas
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