Stains
E selectin / CD62E
Copyright: 2003-2020, PathologyOutlines.com, Inc.
PubMed Search: E Selectin[title]
Selectins: E selectin (CD62E)-below L selectin (CD62L) P selectin (CD62P)
E selectin / CD62E
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2015
Minor changes: 28 August 2020
Copyright: 2003-2020, PathologyOutlines.com, Inc.
PubMed Search: E Selectin[title]
Selectins: E selectin (CD62E)-below L selectin (CD62L) P selectin (CD62P)
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Additional referencesCite this page: Pernick N. E selectin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsselectine.html. Accessed September 29th, 2020.
Definition / general
- Also called CD62E, endothelial (leukocyte) adhesion molecule-1, ELAM1, SELE
- Ligand for sialyl-Lewis X (CD15s); also CD43 (Blood 2006;107:1421), CD44 (J Exp Med 2005;201:1183), CD162/PSGL-1 (Am J Physiol Cell Physiol 2005;289:C415) and tumor cells (Cancer Res 2005;65:5750)
- Inhibited by hCG (Anticancer Res 2005;25:1811)
- Mediates leukocyte rolling (causes slow rolling, which may assist with adhesion) and adhesion to activated endothelium at inflammatory sites
- Also associated with atherosclerosis, tumor cell adhesion during hematogenous metastasis (Cancer Res 2006;66:9117)
- Patients with Leukocyte Adhesion Deficiency 2 syndrome (OMIM 266265), who lack sialyl Lewis X component of selectin counter-receptors, suffer recurrent pyogenic infections
- Homozygosity for Ser128Arg polymorphism associated with recurrent venous thromboembolism (Arch Intern Med 2006;166:1655) and myocardial infarction (Arterioscler Thromb Vasc Biol 2003;23:783), due to increased rolling and adhesion of neutrophils and mononuclear cells, or alteration of lymphocytes binding to E selectin (J Immunol 2002;169:5860)
- Other mutations also associated with vascular disease (Brain Res 2006;1108:221)
- High serum levels associated with insulin resistance in type 2 diabetes (Metabolism 2005;54:376), vascular disease in type 1 diabetes (J Diabetes Complications 2006;20:188), relapse in AML (Hematology 2002;7:83)
Uses by pathologists
- No significant clinical use by pathologists
Microscopic (histologic) images
Images hosted on other servers:
Normal brain and renal carcinoma
Positive staining - normal
- Endothelium after cytokine stimulation
Positive staining - disease
- Endothelium in chronic inflammatory disorders of skin and synovium, hemangiomas (Am J Pathol 1996;148:1181)
Additional references
