Stains & CD markers
Selectins


Topic Completed: 1 June 2015

Minor changes: 12 August 2021

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: E Selectin[title], L selectin[title], P selectin[title]


Nat Pernick, M.D.
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Cite this page: Pernick N. Selectins. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsselectine.html. Accessed October 24th, 2021.
E selectin
L selectin
P selectin
  • Also called CD62P, PADGEM, SELP
  • Interaction with CD162 mediates tethering and rolling of leukocytes on the surface of activated endothelial cells
  • Mediates delivery of lymphocytes to high endothelial venules (with CD62L)
  • A platelet alpha-granule membrane protein that redistributes to the plasma membrane during platelet activation and degranulation
  • Has procoagulant activity (Trends Mol Med 2004;10:179)
  • Constitutive expression in inflammation may contribute to tissue destruction, atherogenesis and thrombosis
  • Reduced expression in:
  • Increased expression in Takayasu's arteritis (Circ J 2006;70:600)
  • Increased serum levels associated with atherosclerosis (Eur Heart J 2003;24:2166)
  • Val640Leu polymorphism is associated with thromboembolic stroke (Hum Mol Genet 2004;13:389)
  • Endothelial P selectin has important role in pathogenesis of cerebral malaria (Am J Pathol 2004;164:781)
  • Promotes metastases by tumor cell binding (Glycobiology 2007;17:185)
  • Uses by pathologists: distinguishing heparin-induced thrombocytopenia without and with thrombosis (Thromb Haemost 1999;82:1255)
  • Positive staining - normal: platelets, megakaryocytes, activated endothelial cells (membranes of Weibel-Palade bodies)
  • Negative staining - normal: sinusoidal endothelium (Am J Pathol 1993;142:481)
  • Reference: OMIM 173610
Microscopic (histologic) images

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E selectin: normal brain, renal carcinoma

L selectin: rat thymus

P selectin: megakaryocytes in bone marrow

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