Stains & molecular markers
P selectin / CD62P

Topic Completed: 1 June 2005

Minor changes: 23 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: P selectin[title]

Selectins: E selectin (CD62E)L selectin (CD62L)  P selectin (CD62P)-below

Nat Pernick, M.D.
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Cite this page: Pernick N. P selectin. website. Accessed January 18th, 2021.
Definition / general
  • Also called CD62P, PADGEM, SELP
  • Interaction with CD162 mediates tethering and rolling of leukocytes on the surface of activated endothelial cells
  • Mediates delivery of lymphocytes to high endothelial venules (with CD62L)
  • A platelet alpha-granule membrane protein that redistributes to the plasma membrane during platelet activation and degranulation
  • Has procoagulant activity (Trends Mol Med 2004;10:179)
  • Constitutive expression in inflammation may contribute to tissue destruction, atherogenesis and thrombosis
  • Reduced expression in gray platelet syndrome (OMIM #139090), advanced melanoma (Am J Pathol 1998;152:679)
  • Increased expression in Takayasu's arteritis (Circ J 2006;70:600)
  • Increased serum levels associated with atherosclerosis (Eur Heart J 2003;24:2166)
  • Val640Leu polymorphism is associated with thromboembolic stroke (Hum Mol Genet 2004;13:389)
  • Endothelial P-selectin has important role in pathogenesis of cerebral malaria (Am J Pathol 2004;164:781)
  • Promotes metastases by tumor cell binding (Glycobiology 2007;17:185)
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Megakaryocytes in bone marrow

Positive staining - normal
  • Platelets, megakaryocytes, activated endothelial cells (membranes of Weibel-Palade bodies)
Negative staining - normal
Additional references
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