Stains & molecular markers
Survivin


Topic Completed: 1 June 2005

Minor changes: 23 December 2020

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: Survivin[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Survivin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainssurvivin.html. Accessed June 23rd, 2021.
Definition / general
  • Inhibitor of apoptosis protein; may also enhance proliferative activity of tumor cells
  • Overexpression enhances cell survival
Interpretation
  • Cytoplasmic staining
Positive staining - normal
  • Fetal tissues
Positive staining - disease
  • Hepatocellular carcinoma, endometrial carcinoma
Negative staining
  • Most normal, terminally differentiated tissue
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