Stains & molecular markers

Topic Completed: 1 November 2013

Minor changes: 24 December 2020

Copyright: 2013-2021,, Inc.

PubMed Search: TAK1[title] or MAP3K7[title]

Nat Pernick, M.D.
Page views in 2020: 86
Page views in 2021 to date: 11
Cite this page: Pernick N. TAK1 / MAP3K7. website. Accessed January 20th, 2021.
Definition / general
  • TGF-β activated kinase-1 (Tak1), is a serine/threonine kinase and MAP3 kinase; is a key regulator in inflammatory and immune signaling pathways (Trends Pharmacol Sci 2012;33:522)
  • Activated by TGF-β; also TNF, IL1, CD40 ligand, toll-like receptors, T- and B-cell receptors; upon activation, activates IκK, p38 MAPK, c-jun N-terminal kinase, leading to activation of NF-κB and activator protein-1 transcription factors, which mediate various inflammatory cytokines involved in inflammation, immunity and cell death (Blood 2012;120:347)
  • Putative prostate tumor suppressor gene
  • TAK1 is an essential component in genotoxic stress-induced NF-κB activation, associated with chemoresistance (Apoptosis 2013;18:1224)
    • TAK1 ubiquitination plays critical roles in regulation of Doxycycline induced NF-κB activation (Cell Signal 2013;25:247)
  • Involved in at least five signaling cascades that modulate ischemic brain damage; inhibition may be protective against ischemic stroke (Exp Neurol 2013;239:68)
  • Also associated with human longevity (Age (Dordr) 2013;35:1357)
Uses by pathologists
  • No specific uses at this time
Microscopic (histologic) images

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Head and neck: squamous cell carcinoma

Lymphoma: cell lines

Prostate: benign and malignant

Prostate carcinoma

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